The purpose of this website is to provide training in performing histopathological assessment of response to neoadjuvant chemotherapy in advanced stage high-grade serous carcinoma.
This is done by assignment of a
There are 20 cases and for each case there is a single slide of omentum, selected as the section of omentum that shows the most residual viable tumor post-chemotherapy.
The 20 cases are divided into 10 cases as a TRAINING SET; for each of these cases you can review the slide, choose a CRS score from 1 to 3, as per the guidelines below, and click on the result tab to immediately see the score assigned by the study pathologists. There are also 10 cases in the TEST SET; for this series of 10 scanned slide images you choose a score, and when you have completed all 10 slides you will be given your results for the series, compared to the CRS scores assigned by the study pathologists.
CRS score 1: No or minimal tumour response (mainly viable tumour with no or minimal regression-associated fibro-inflammatory changes, limited to a few foci)
CRS score 2: Appreciable tumour response with residual tumour, (ranging from multifocal or diffuse fibro-inflammatory regressive changes, with tumour in sheets, streaks or nodules, to extensive regression associated fibro-inflammatory changes with multifocal residual tumour which is regularly distributed and easily identifiable)
CRS score 3: Complete or near-complete response (mainly regression associated fibro-inflammatory changes with minimal i.e. very few, irregularly scattered individual tumour cells or cell groups or nodules up to 2mm OR no residual tumour identified)
To start, click on the TRAINING SET link, below. After reviewing the training set cases, please proceed to the TEST SET.
TRAINING SET (10 cases)
TEST SET (10 cases)
© Genetic Pathology Evaluation Centre